March 20, 2013
Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis
Patients with MS who are vitamin D deficient should be supplemented...
>> moreMarch 20, 2013
Potential Immune Benefits of Strong Vitamin D Status in Healthy Individuals
Research shows that improving vitamin D status by increasing its level in the blood could have a number of non-skeletal health benefits. The study reveals for the first time that improvement in the ...
>> moreMarch 1, 2013
Oxford Neurologist Awarded Dystel Prize for MS Research
George C. Ebers, MD, a leading researcher with the University of Oxford and Oxford University Hospitals Trust in Oxford, United Kingdom has focused his research on genetic and environmental influences on MS risk.
>> moreFebruary 23, 2013
Is a vitamin D deficit a cause or an effect of MS?
Barts and UCLP Research Day Question Time Question #5.
February 6, 2013
Yes, if I had clinically isolated syndrome with magnetic resonance imaging diagnostic of multiple sclerosis, I would take vitamin D 10,000 IU daily
Strong epidemiologic evidence supports a role for vitamin D insufficiency as a risk factor for multiple sclerosis (MS), shown by increasing disease prevalence with increasing latitude, and inverse correlation with duration and intensity of ultraviolet B (UVB) sunlight exposure and vitamin D serum concentration.
>> moreFebruary 6, 2013
No, if I had a clinically isolated syndrome with MRI diagnostic of MS, I would not take vitamin D 10,000 IU daily
We believe that conclusive demonstration of the efficacy in MS is still missing, and that the links between 25OH vitamin D intake, vitamin D status, and neurologic outcome remain hypothetical.
>> moreFebruary 6, 2013
Commentary, if I had CIS with MRI diagnostic of MS, I would take vitamin D 10,000 IU daily
If the debate question was framed as “Would I prescribe vitamin D 10,000 units to a patient with clinically isolated syndrome and an abnormal MRI scan?”, then the answer is, of course, “No”. I agree with the antagonists in this debate that phase 3 trial data are needed before using vitamin D as a therapeutic agent. However, those trial data will take at least another 2-3 years to collect. Thus, while waiting for that proof, if I, or my children, developed a clinically isolated syndrome with an abnormal MRI scan, then I would have no hesitation in prescribing vitamin D in that dose for them.
>> moreDecember 19, 2012
Preventive effect of vitamin D3 supplementation
50,000 IU of vitamin D3 weekly for 12 months may delay the onset of a second clinical attack and the subsequent conversion to MS.
>> moreNovember 19, 2012
Multiple Sclerosis Linked to Vitamin D Levels, Study Says
People with high levels of vitamin D in their blood have shown a lower risk of developing multiple sclerosis, according to results of a Swedish study released Monday.
>> moreNovember 15, 2012
Are you pregnant or planning to fall pregnant?
Professor Gavin Giovannoni:
"If you are pregnant or planning to fall pregnant you need to make sure you are vitamin D replete. This may lower the chances of your child getting MS and other autoimmune diseases. My recommendation for pregnancy is 10,000U vD3 per day; this is double my recommendation of 5,000U per day for adults."
>> moreNovember 14, 2012Month of Birth Effect: Give Pregnant Women Vitamin D Supplements to Ward Off Multiple Sclerosis, Say Researchers
The risk of developing multiple sclerosis is highest in the month of April, and lowest in October, indicates an analysis of the available evidence, published online in the Journal of Neurology ...
>> moreOctober 19, 2012Effect of high-dose vitamin D3 intake on ambulation, muscular pain and bone mineral density in a woman with multiple sclerosis: a 10-year longitudinal case report
Since January 2001, a vitamin D3 supplement was ingested daily. The starting dose was 20 mcg (800 IU)/day and escalated to 100 mcg (4000 IU)/day in September 2004 and then to 150 mcg (6000 IU)/day in December 2005. Vitamin D3 intake reduced muscular pain and improved ambulation from 1 (February 2000) to 14 km/day (February 2008).
>> moreOctober 17, 2012
Prevention of MS
Through rigorous epidemiological investigation, Epstein-Barr virus infection, vitamin D nutrition and cigarette smoking have been identified as likely causal factors in MS.
>> moreOctober 16, 2012
Australia rolls out world first MS prevention trial
One of the most important developments in the prevention of multiple sclerosis (MS) is a world first clinical trial set to take place in Australia and New Zealand. It will test whether vitamin D can prevent MS in those at risk of developing the disease.
PrevANZ – vitamin D MS prevention trial FAQ PDF (152 KB)October 13, 2012
Shedding some light on vitamin D and MS - ECTRIMS 2012
We all know that having proper levels of vitamin D is important to our overall general health. But scientists are continuing to gain more understanding about the link between vitamin D levels and what it means to people living with MS.
October 10-13, 2012
28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis - ECTRIMS 2012
Abstracts Vitamin D
October 3, 2012
Low vitamin D levels linked to more severe multiple sclerosis symptoms
Low blood levels of vitamin D are associated with an increased number of brain lesions and signs of a more active disease state in people with multiple sclerosis (MS), a new study finds, suggesting a potential link between intake of the vitamin and the risk of longer-term disability from the autoimmune disorder.
August 30, 2012
Prenatal Vitamin D Deficiency Induces an Early and More Severe Experimental Autoimmune Encephalomyelitis in the Second Generation
The vitamin D deficiency affecting the F0 pregnant mice induced a precocious and more severe EAE in the F2 generation. In MS patients a trend for a reduced number of births in the Fall for their parents was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding.>> more
July 26, 2012Vitamin D and MS, Q&A with Dr. Collene Hayes
Dr. Colleen Hayes, PhD, professor of biochemistry at the University of Wisconsin-Madison about "Solving the Multiple Sclerosis Problem: A Role for Vitamin D".
July 25, 2012
Vitamin D may reduce the risk of dominantly inherited Alzheimer’s disease
Higher serum 25(OH)D concentrations may reduce the risk of Alzheimer’s disease. Based on results from other studies, serum 25-hydroxyvitamin D concentrations should be above 40 ng/ml (100 nmol/l) for optimal health.
July 17, 2012
Interferon-beta increases vitamin D levels from sun exposure
Bruce Taylor highlighted the fact that all those patients who were given Interferon-beta were far more efficient in producing vitamin D in their skin. They had nearly three times more vitamin D than those who were not on the treatment.
July 13, 2012
Relationship between 25OHD serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation
A study in which 156 RRMS patients were supplemented for 2,5 years with a moderate vitamin D dose (3000 IU/day) has reported a marked reduction of relapses (more than 50%). The vitamin D3 supplementation increasing vitamin D serum levels, up to 110 nmol/L (44 ng/ml), with a plateau effect beyond this level. Suggesting, therefore, that it is particularly useful to correct vitamin D deficiency in MS patients when present. Vitamin D deficiency (< 100 nmol/L) is present in 90% of the MS patients. Furthermore, because of the plateau effect beyond 110-120 nmol/L, it may not be necessary to prescribe high, not physiological vitamin D doses (beyond 4000 IU/day).
July 5, 2012
Higher Doses of Vitamin D - 800 IU and 2000 IU - per day Are Effective in Fracture Risk Reduction in Older Adults, Study Suggests
Based on the results of a pooled analysis of 11 unrelated randomized clinical trials investigating vitamin D supplementation and fracture risk in more than 31,000 older adults, scientists say higher...
June 13, 2012
Vitamin D in MS A vitamin for 4 seasons
The results of 3 independent studies published in Neurology® suggest that higher levels of circulating 25-hydroxyvitaminD (25OHD) may reduce relapses and lesions on MRI in persons with multiple sclerosis (MS). It is too soon to recommend the use of high-dose vitamin D in clinical practice. Meanwhile, considering the high prevalence of vitamin D insufficiency and deficiency in persons with MS, the high risk of osteoporosis, and the safety of vitamin D at modest doses, the evidence is sufficient to recommend monitoring of vitamin D levels and supplementation as needed to achieve at least a year-round level of vitamin D sufficiency in persons with MS.
June 13, 2012
Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis
Our finding that higher vitamin D levels are associated with decreased exacerbation risk in relapsing-remitting MS suggests a beneficial effect of vitamin D on disease course in MS. However, the possibility of reverse causality cannot be ruled out completely. Randomized intervention studies are therefore needed to investigate the effect of vitamin D supplementation in MS.
June 13, 2012
Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS
In this study, we found that IFN-β therapy is associated with greater production of vitamin D from sun exposure, suggesting part of the therapeutic effects of IFN-β on relapse in MS may be through modulation of vitamin D metabolism. These findings suggest persons being treated with IFN-β should have vitamin D status monitored and maintained in the sufficiency range.
June 13, 2012
Vitamin D and disease activity in multiple sclerosis before and during interferon-β treatment
Increasing levels of 25-hydroxyvitamin D are inversely associated with a significant and consistent reduction of active lesions on MRI in untreated patients with MS. A randomized controlled trial sufficiently powered to capture moderate, but still potentially important effects, is needed to prove a causal relationship between vitamin D levels and disease activity in MS.
June 11, 2012
ENS Congress: High level of vitamin D reduces risk of multiple sclerosis
European Neurological Society 2012: 3,000 neurologists meet in Prague. Oral administration of vitamin D is recommended for individuals with a vitamin D deficiency and for those who already have MS.
>> moreApril 19, 2012
MS Trial Alert: Trial of Vitamin D Supplementation Recruiting People with Relapsing-Remitting MS
Investigators at several centers in the USA are recruiting 172 people with relapsing-remitting MS to compare the effectiveness of the current recommended amount of vitamin D supplementation versus high dose vitamin D supplementation at reducing MS disease activity, when added to standard therapy with glatiramer acetate (Copaxone®, Teva Pharmaceutical Industries).
April 18, 2012
Common Virus Plus Low Sunlight Exposure May Increase Risk of Multiple Sclerosis
New research suggests that people who are exposed to low levels of sunlight coupled with a history of having a common virus known as mononucleosis may be at greater odds of developing multiple sclerosis (MS) than those without the virus.
March 20, 2012
Vitamin D status predicts new brain MRI activity in multiple sclerosis
Mowry EM et al. – Vitamin D levels are inversely associated with multiple sclerosis (MS) activity on brain MRI. These results provide further support for a randomized trial of vitamin D supplementation.>> more
March 19, 2012
Human skin pigmentation, migration, and disease susceptibility
Human skin pigmentation evolved as a compromise between the conflicting physiological demands of protection against the deleterious effects of ultraviolet radiation (UVR) and photosynthesis of UVB-dependent vitamin D3.
>> audio supplement
>> TED TALKS: Nina Jablonski breaks the illusion of skin color
March 10, 2012
Vitamin D News for Multiple Sclerosis Patients, March 2012
Dr. C.E. Hayes, Professor of Biochemistry, U. Wisconsin
>> more (160 KB)
February 26, 2012Vitamin D prevention trial for MS will commence in 2012
The PrevANZ vitamin D clinical trial for prevention of MS is the world first prevention trial for MS. It is set to begin in Australia, using Vitamin D to prevent repeat attacks of Multiple Sclerosis. The PrevANZ trial will test 3 dosage levels of daily vitamin D supplements (1000, 5000 & 10,000 International Units) against placebo (dummy tablets).
February 22, 2012
Vitamin D Could Be Weapon Against MS
A clinical trial will test whether Vitamin D can help fight multiple sclerosis (MS). If successful, researchers say the trial could open the door to a treatment which is 100 times cheaper than other drugs available.
>> moreFebruary 22, 2012
A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon β-1b in patients with multiple sclerosis
One year supplementation with 20,000 IU vitamin D(3) weekly and no calcium daily raised the mean serum 25-hydroxy vitamin D (25[OH]D) from 54 to 110 nmol/L. 84% of patients reached a serum 25(OH)D level > 85 nmol/L in the vitamin D group and 3% in the placebo group. Patients in the vitamin D group showed fewer new brain lesions. Vitamin D3 add on treatment to IFNB reduces MRI disease activity in MS.
>> moreFebruary 21, 2012
Effect of vitamin D3 supplementation on relapses, disease progression and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial
Two year supplementation with 20,000 IU vitamin D(3) weekly and 500 mg calcium daily raised median serum 25-hydroxy vitamin D (25[OH]D) to 121 nmol/L. Unfortunately, the sample size was too small to result in beneficial effects on the measured multiple sclerosis-related outcomes.
>> moreFebruary 2, 2012Dangers of vitamin D deficiency highlighted
Following fresh concerns about vitamin D deficiency, the UK’s 4 Chief Medical Officers have written to health professionals reminding them about this issue.
>> moreJanuary 27, 2012England's chief medical officer Dame Sally Davies backs (free) vitamin D supplements
England's chief medical officer Dame Sally Davies has begun campaigning to the English medical fraternity that certain population groups like under-5s should take vitamin D supplements.
>> moreJanuary 17, 2012
National MS Society Convenes Summit to Explore Vitamin D Trials to Prevent MS
An International Workshop “Vitamin D and MS Prevention" discussed the latest findings relevant to vitamin D and MS and potential clinical trial designs, taking the first steps to making these exciting studies a reality.
>> moreDecember 20, 2011
Vitamin D in food call to combat Scots MS
Prof George Ebers, a University of Oxford professor, has said rates of multiple sclerosis are so dire in Scotland essential foodstuffs should be fortified with vitamin D.
>> moreDecember 13, 2011
From the Frontlines: What’s New in MS Research for 2012
Researchers have just finished an exciting summit asking the question, can we prevent MS with Vitamin D?
>> watch the recording
or >> read the transcript
December 8, 2011
Rare Gene Links Vitamin D and Multiple Sclerosis
Prof George Ebers, lead study author at Oxford University, says "This type of finding has not been seen in any complex disease. The uniform transmission of a variant to offspring with MS is without precedent but there will have been interaction with other factors."
October 19 - 22, 2011
Breaking News from ECTRIMS/actrims: Zeroing in on risk factors for MS
Research has now shown that Vitamin D3 (Cholecalciferol) can, not only prevent MS, but also can reduce MS-attacks, MS-lesions in the Brain as seen on the MRI and also reduce the progression of MS. Thus Vitamin D3 may even prevent the wheel chair. These findings have to be re-established in larger clinical trials.
>> moreAugustus 23 , 2011Vitamin D Found to Influence Over 200 Genes, Highlighting Links to Disease
The extent to which vitamin D deficiency may increase susceptibility to a wide range of diseases is dramatically highlighted in newly published research. Scientists have mapped the points at which
>> moreAugustus 10 , 2011
Global Consortium Doubles the Number of MS Risk Genes Identified
Two genes linked to vitamin D were also implicated; research is increasingly pointing to low vitamin D levels in patients as a risk factor for developing MS.
>> moreJuly 11 , 2011Poor Bone Health May Start Early in People With Multiple Sclerosis
Osteoporosis and low bone density are common in people in the early stages of multiple sclerosis (MS), according to a new
May 22 , 2011Epstein-Barr Virus Could Be Risk Factor for Multiple Sclerosis
While there is no cause known for multiple sclerosis, patients with MS seem to have genetic vulnerability to certain environmental factors that could trigger this condition, such as the Epstein-Barr
April 19 , 2011Common Virus Plus Low Sunlight Exposure May Increase Risk of Multiple Sclerosis
New research suggests that people who are exposed to low levels of sunlight coupled with a history of having a common virus known as mononucleosis may be at greater odds of developing multiple sclerosis.
April 12 , 2011
Gestational ultraviolet and vitamin D exposure and the risk of multiple sclerosis in the United Kingdom
One of the most enigmatic features of the complex disease multiple sclerosis (MS) is the observation that season of birth influences the risk of developing the disease later in life being higher in spring born and lower in fall born individuals.
>> moreMarch 3 , 2011How Sunlight May Reduce the Severity of Multiple Sclerosis
New research into the neurodegenerative disease, multiple sclerosis (MS) offers new insight into the link between sunlight, vitamin D3, and MS risk and severity. The research studies the relationship
February 7, 2011Sun Exposure, Vitamin D May Lower Risk of Multiple Sclerosis
People who spend more time in the sun and those with higher vitamin D levels may be less likely to develop multiple sclerosis, according to a new study. MS is a chronic disease of the brain and
December 2 - 4, 2010
Vitamin D: A Health/Disease Switch in MS
There is mounting evidence that alterations in the gastro-intestinal microbiota (due to lifestyle changes) have disrupted microbial-mediated mechanisms of immunological tolerance within and outside the gut and can affect various immunologic diseases in humans.
>> moreOctober 15, 2010
Vitamin D News for Multiple Sclerosis Patients, October 2010
Dr. C.E. Hayes, Professor of Biochemistry, U. Wisconsin, Editor
>> moreMay 22, 2010
Vitamin D News for Multiple Sclerosis Patients, May 2010
Dr. C.E. Hayes, Professor of Biochemistry, U. Wisconsin, Editor
>> moreApril 10 - 17, 2010Abstracts/talks on vitamin D and MS at the 62nd Annual Meeting of the American Academy of Neurology (AAN)
>> moreMarch 8, 2010
Vitamin D Crucial to Activating Immune Defenses
Scientists have found that vitamin D is crucial to activating our immune defenses and that without sufficient intake of the vitamin - the killer cells of the immune system -- T cells -- will not be
October 23, 2009Why governments are selling Vitamin D short
and other vitamin D researchers around the world believe they can prove vitamin D could help millions live longer and be healthier and yet they have not been able to convince their own governments.
>> moreFebruary 06, 2009
Study Shows Link Between Vitamin D and an MS Susceptibility Gene
For the first time, researchers have found evidence of a direct interaction between vitamin D and a common genetic variant, the presence of which increases the risk of developing multiple sclerosis. The research highlights the importance of studying the interaction of genes and the environment to search for the underlying triggers of this complex disease.
>> moreJanuary 27, 2009Study Linking Vitamin D to a Reduction in Cancer Risk
A total of 2,300 women will be recruited and followed for four years with half of the participants randomly assigned to take daily supplements containing 2,000 IU of vitamin D3 and 1,200 mg of calcium; the second group will receive placebos.
>> moreJanuary 7, 200925-hydroxyvitamin D levels and the risk of mortality in the general population
In the study, people who had low vitamin D levels, 17.8 ng/mL (44.5 nmol/L) or lower, were 26 percent more likely to be dead at the end of the study than those with higher vitamin D levels.
>> moreJanuary 1, 2009An International Effort to Solve the Vitamin D Deficiency Epidemic
Sign up to participate in this study and get your vitamin D tested with a blood spot test from ZRT.